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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN22
All Species:
22.73
Human Site:
S159
Identified Species:
50
UniProt:
Q9Y2R2
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2R2
NP_057051.3
807
91705
S159
E
F
G
P
F
S
V
S
C
E
A
E
K
R
K
Chimpanzee
Pan troglodytes
XP_513663
807
91678
S159
E
F
G
P
F
S
V
S
C
E
A
E
K
R
K
Rhesus Macaque
Macaca mulatta
XP_001110241
807
91482
S159
E
F
G
P
F
S
I
S
C
E
A
E
K
R
K
Dog
Lupus familis
XP_540240
893
101055
S244
Q
L
G
P
F
S
I
S
C
E
A
E
N
R
K
Cat
Felis silvestris
Mouse
Mus musculus
P29352
802
89696
S159
Q
F
G
P
F
S
I
S
C
E
A
E
K
K
K
Rat
Rattus norvegicus
NP_001099930
804
89584
S159
Q
F
G
P
F
S
I
S
C
E
T
E
K
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506530
800
89754
Y152
E
N
I
K
K
N
R
Y
K
D
I
L
P
F
D
Chicken
Gallus gallus
XP_001235234
775
85980
E133
V
M
A
C
M
E
F
E
M
G
K
K
K
C
E
Frog
Xenopus laevis
NP_001084841
660
74123
D18
I
Q
R
V
Q
E
M
D
M
K
D
H
N
G
E
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
Q165
F
G
D
I
L
V
T
Q
I
G
Q
Q
R
V
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.5
71.1
N.A.
71.1
69.2
N.A.
57.1
50.8
36.3
34.3
N.A.
N.A.
N.A.
N.A.
28.2
Protein Similarity:
100
99.8
97
77.9
N.A.
80.4
79.3
N.A.
68
64
50.9
49.9
N.A.
N.A.
N.A.
N.A.
44.7
P-Site Identity:
100
100
93.3
73.3
N.A.
80
73.3
N.A.
6.6
6.6
0
0
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
86.6
N.A.
100
93.3
N.A.
20
20
20
0
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
0
0
46
0
0
0
0
% A
% Cys:
0
0
0
10
0
0
0
0
55
0
0
0
0
10
0
% C
% Asp:
0
0
10
0
0
0
0
10
0
10
10
0
0
0
10
% D
% Glu:
37
0
0
0
0
19
0
10
0
55
0
55
0
0
19
% E
% Phe:
10
46
0
0
55
0
10
0
0
0
0
0
0
10
0
% F
% Gly:
0
10
55
0
0
0
0
0
0
19
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% H
% Ile:
10
0
10
10
0
0
37
0
10
0
10
0
0
0
0
% I
% Lys:
0
0
0
10
10
0
0
0
10
10
10
10
55
19
55
% K
% Leu:
0
10
0
0
10
0
0
0
0
0
0
10
0
0
0
% L
% Met:
0
10
0
0
10
0
10
0
19
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
10
0
0
0
0
0
0
19
0
0
% N
% Pro:
0
0
0
55
0
0
0
0
0
0
0
0
10
0
0
% P
% Gln:
28
10
0
0
10
0
0
10
0
0
10
10
0
0
0
% Q
% Arg:
0
0
10
0
0
0
10
0
0
0
0
0
10
37
0
% R
% Ser:
0
0
0
0
0
55
0
55
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
10
0
0
0
10
0
0
0
10
% T
% Val:
10
0
0
10
0
10
19
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _